![]() Rischin: Travel/Accommodation/Expenses: Merck Research grant/Funding (self): Genentech/Roche, Merck, Regeneron, Bristol-Myers Squibb, GlaxoSmithKline, Sanofi. Greil: Advisory/Consultancy: Celgene, Novartis, Roche, Bristol-Myers Squibb, Takeda, AbbVie, AstraZeneca, Janssen, MSD, Merck, Gilead Sciences, Daiichi Sankyo Travel/Accommodation/Expenses: Rocher, Amgen, Janssen-Cilag, AstraZeneca, Novartis, MSD, Celgene, Gilead Sciences, Bristol-Myers Squibb Honoraria (self): Celgene, Roche, Merck, Takeda, AstraZeneca, Novartis, Amgen, Bristol-Myers Squibb, MSD, Sandoz, AbbVie, Gilead Sciences, Daiichi Sankyo Research grant/Funding (institution): Celgene, Merck, Takeda, AstraZeneca, Novartis, Amgen, Bristol-Myers Squibb, MSD, Sandoz, Gilead Sciences, Roche. Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc., Kenilworth, NJ, USA. ![]() This assistance was funded by Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc., Kenilworth, NJ, USA. Medical writing and editorial assistance was provided by Doyel Mitra, PhD, CMPP, and Jo Bairzin, PhD, of the ApotheCom pembrolizumab team (Yardley, PA, USA). *Nominal values not adjusted for multiplicity. ![]() Safety was favorable for pembro vs E and comparable for pembro+C vs E Table: 915MO Long-term follow-up confirmed the statistically significant improvement in OS established at the protocol-specified interim and final analyses for pembro vs E in pts with PD-L1 CPS ≥20 and CPS ≥1 and for pembro+C vs E in pts with PD-L1 CPS ≥20 and CPS ≥1, and total pop. In all, 11 pts (pembro, 6 pembro+C, 5) received a secondcourse of pembro ORR for second course was 36.4% (CR, 1 PR, 3). Treatment-related grade 3-5 AEs: 17.0% for pembro, 71.7% for pembro+C, and 69.3% for E. OS, PFS, ORR, and DOR data are shown in the table. Pembro and pembro+C improved OS vs E in the CPS ≥20, CPS ≥1, and total pops (Table). Median study follow-up (March 25, 2020) was 46.2 mo for pembro vs E and 45.6 mo for pembro+C vs E. Efficacy was analyzed in the ITT pop safety was analyzed in all randomized pts who received ≥1 dose of study drug. ![]() Follow-up was defined as time from randomization to database cutoff. Pts in the pembro or pembro+C arms who stopped pembro with stable disease or better and then had PD could receive a second course of pembro if eligible. Pts with locally incurable R/M HNSCC were randomized to 1L pembro 200 mg Q3W for 24 mo, pembro+C, or E. Safety was favorable for pembro vs E and comparable for pembro+C vs E. Pembro+C significantly prolonged OS vs E in the PD-L1 CPS ≥20, CPS ≥1, and total pops. In the phase III KEYNOTE-048 study, pembro significantly prolonged OS vs E in patients (pts) with PD-L1 combined positive score (CPS) ≥20 and CPS ≥1 and had noninferior OS in the total population (pop).
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Fourth and fifth entries in the series, developed by Koalabs and published by Anuman, appeared in 2013. After Dracula 2 's release, the Dracula series went on hiatus until the 2007 announcement of Dracula 3: The Path of the Dragon by Kheops Studio and MC2 France. Dracula and its direct sequel, Dracula 2: The Last Sanctuary (2000), reached combined global sales above 1 million units by April 2007. In North America, it became a top title for DreamCatcher and sold 170,000 units by 2003. Blu-ray reviews, releases, news, guides and forums covering Blu-ray movies, players, recorders, drives, media, software and. Selling 200,000 units worldwide by September 2000, the game was a commercial success. Reviewers praised the game's graphics and some of the puzzles, but criticized the voice acting, plot and the game's brevity. There were dubbing mutations in French, English, Spanish, German, Italian and Czech.ĭracula received "mixed or average" reviews from critics, according to Metacritic. ![]() In North America, it was published by DreamCatcher Interactive the following year. Dracula: The Last Sanctuary, and Dracula 3: The Path of the Dragon. The game underwent a rapid development cycle of 8 months, and was first launched in Europe in October 1999. Dracula pc game The Dracula Trilogy pack includes Dracula: The Resurrection. Building from myths, legends, Bram Stoker's novel and films about vampires, Dracula 's creators sought to create a follow-up to Stoker's story that was imbued with the same atmosphere of dread as its predecessor. ![]() It was the company's first traditional video game: the team had previously created software with an educational and cultural tourism emphasis, a style that informed Dracula 's design. ![]() Production of Dracula was led by Jacques Simian of Index+. Sleep and mental health are seriously connected. Basically, if you didn’t get enough sleep last night, then take the bus to school so you don’t crash your mom’s car and be warned, your performance in math class is gonna suck. Specifically, people who lack sleep have trouble with auditory and visuo-spatial attention, performing addition and subtraction tasks, and their reaction times are poor. Sleep deprivation screws with your memory and concentration, too. When you don’t get enough sleep, your cytokine pr oduction decreases, putting you at risk of getting sick more easily. Our immune systems help us to fight off infection, inflammation and disease by releasing proteins called cytokines. Lack of sleep messes up your immune system. Research has shown that teens with low stress sleep more hours per night than teens with high stress (7.8 vs. Sleep decreases stress and increases resiliency. At your age, research indicates that sleep is more important than when you were 10 years old, because your brain is going through another big developmental stage that’s supported by proper rest. ![]() Sleep is as vital to your well-being as air, water and food. This is the reason that some smart adults are lobbying for a later start time for high schoolers. You’re likely getting around seven hours MAX and so, you’re putting yourself at risk for lots of problems with your immune system, mental health, concentration, memory and, yes, your complexion. That’s only an issue because you require about eight to 10 hours of sleep to function at your best, and most of you are waking up at 6 am on school days, after staying up late working on class projects, enjoying extracurriculars or perhaps pulling an evening shift at a part-time job. In adolescence, it’s natural to have a hard time falling asleep before 11 pm. I’m sure you’ve noticed that you get tired much later than you did a few years ago. It’s hard to manage your sleep when your biological sleep patterns have shifted, but your school bell still rings super early. I can cut you some slack, knowing that many of your night-owl-like ways have to do with your changing body and circadian rhythms. Plus, I was once a sleep-deprived teenager, myself. Not only do I have one of you at home, but I spend all day every day with teens just like you. Look, you don’t have to explain yourself to me. Sleep is everything-but you don’t realize it. ![]() Arkham Asylum (3 Stage Transitions: Front Gates, Cell Block & Mess Hall).Merry X-Mas Customization Pack (Superman, Killer Frost & Booster Gold).Halloween Customization Pack (Solomon Grundy, Batman & Doomsday).Apokolips War Customization Pack (Darkseid, Mister Miracle & Zod).Brightest Days Customization Pack (Batman, Hawkgirl & Swamp Thing). ![]() Gold Age Customization Pack (The Flash, Green Lantern & Booster Gold).Silver Screen Customization Pack (Wonder Woman, Aquaman & Shazam). ![]()
![]() 3 #17-18, Quasar #22-24, Punisher War Journal #29-30Īfter #18: Marvel Comics Presents #90-97, Spirits of Vengeance #7-8, Marvel Holiday 1991 (may just be a pin-up?), Marvel Comics Presents #98-100 ![]() ![]() Strange #28, Moon Knight #35, Spider-Man #6-7, Damage Control, Vol. Want to learn more about this run? Read my post on the potential to collect it as an omnibus.Īfter #6, Fantastic Four #347-349 is an infamous sequence where the FF is replaced by Ghost Rider, Wolverine, Spider-Man, and Hulk.Īfter #6 or 9 (unclear): Marvel Comics Presents #64-71Ĭollects #11-20, though #19-20 comes after the next few guest apperances.Īfter #12: Dr. ![]() ĭespite Johnny Blaze’s lengthy history in comics, for many readers introduced to Marvel in the 90s with no access to the 70s series it is Ketch who is the true Ghost Rider. Ghost Rider was the perfect addition to the anti-hero mix, and Marvel made the masterful move of maintaining the character’s legacy while introducing a new host for the Rider – Danny Ketch. Marvel was nearing its peak of sales in 1990, with vigilante characters like Wolverine and Punisher surging in popularity. 3 #11, Team America #11Īfter #81: As Johnny Blaze in Defenders #145-146 Ghost Rider, Vol. #68-81: Reprinted in color in The Original Ghost Rider Rides Again (1991) #1-7Īfter #74: Marvel Super-Heroes Vol. 3 b&wĪlso collects Marvel Two-in-One #80, Marvel Super-Heroes Fall 1992, and Avengers #214.Īfter #62: Marvel Graphic Novel 1, Avengers #214 2, Champions #17, & Sensation Spider-Man #17-18 3: Trials and Tribulations and Ghost-Racers, both below.Īfter #21: Marvel Treasury Edition #13, Champions #11-13Īfter #24: Marvel Team-Up #58, Champions #14-15Īfter #25: Human Fly #2, Iron Man Annual 4, Super-Villain Team-Up #14, Champions #16, Giant-Size Hulk Vol. #35: Collected in color in Ghost Rider, Vol. 2 b&wĬollects Marvel Team-Up #91, Marvel Two-in-One #80, Marvel Premiere #28, Avengers #214 and Ghost Rider #27 & #50. Issues #19-20 are also collected in Essential Daredevil, Vol. 1 b&wĪlso collects Daredevil #138, which continues from #19. Marvel Spotlight #5-11 & Ghost Rider, Vol. Johnny Blaze graduated into his own title in September 1973. The series was acting as a horror anthology at the time, having just launched both Red Wolf and Werewolf by Night into their own series. The modern concept of Ghost Rider debuted in Marvel Spotlight in 1972. Ghost Rider – Johnny Blaze / Zarathos (1972 – 1983) Phantom Rider made further appearances in the 1970s in Western Gunfighters #1 & 6, Giant-Size Kid Colt #3, and Avengers #142-143. This character originated in a Magazine Enterprises comic in 1951-52, which Marvel took advantage of after the trademark had lapsed. Though he was called Ghost Rider at the time, this character was later retconned to be named Phantom Rider – as well as made part of the modern Ghost Rider legend. Join the Crushing On Crushing Krisis mailing list for a notice whenever this page is updated with new collections – plus, a not-more-than-weekly ping about new comics content. All-New, All-Different Marvel: Ghost Rider & Spirits of Vengeance.Marvel Now: All-New Ghost Rider – Robbie Reyes (2014 – 2015).5: The Road to Damnation – Johnny Blaze / Zarathos (2005 – 2006) 3: The Midnight Sons – Ketch & Blaze (1992 – 1994) Over the years, at least five Marvel characters have carried the title, as well as several spirits. Ghost Rider is the rare classic Marvel hero whose name is just a title given to a skull-headed, vengeance-seeking rider (or sometimes driver) possessed by a demonic spirit. Find every issue and appearance! Part of Crushing Krisis’s Crushing Comics.Last updated November 2018 with titles scheduled for release through May 2019. The Ghost Rider comic books definitive issue-by-issue collecting guide and trade reading order for omnibus, hardcover, and trade paperback collections. ![]() Auch das Interieur besticht durch edelste Materialen. Bestechend aber war vor allem die ausgezeichnete Straßenlage – hier kamen die Sportwagengene der Luxuslimousine richtig durch. War die erste Serie noch die schnellste Limousine der Welt, so war die dritte Serie, die 1979 auf den Markt kam, zwar etwas langsamer, hatte aber immer noch ausreichend Dampf, um eine ordentliche Reisegeschwindigkeit jenseits der 200 km/h zu ermöglichen. Wer als Klassiker eine Luxuslimousine mit ordentlich Power, sportlicher Straßenlage und schickem italienischen Blechkleid sucht – der landet zwangsläufig beim Viertürer von Maserati. And then met a deer in South Carolina.ĭer Maserati Quattroporte Serie 3 – Italiens sportliche Luxuslimousine The Coupe story ends with a discussion of Jason's nephew's Infiniti G35 Coupe, which started its journey at a 24 Hours of Lemons race in San Francisco and Teen Driving School at Thunderhill Raceway and drove cross-country - and Tail of the Dragon. And Honda Prelude, Acura Integra, Camry Coupe, Lexus SC, and Buick Reatta. And the discussion of Maserati Quattroporte versus GranCoupe. And then there's the non-Mercedes: BMW E28 M5, the E30 325i, E36 M3, E31 850i. To say nothing of the W201 190E 2.3-16 with its triumphant debut at the grand opening of the Nürburgring GP circuit in a one-marque race won by none other than Ayrton Senna. In this episode, Jason Cammisa and Derek Tam-Scott ("Hyphen") discuss the collectible and awesome sedan - everything from the Mercedes 6.9 and 6.3 to the W124 500E, and the AMG Hammer and Hammer Wagon 500E 6.0. But history was wrong - these days, sedans are doing just fine. ![]() Historically, sedans were viewed as non-collectibles. On earlier OSes, acts like Ctrl + Escape. Ctrl + Alt + Delete or Ctrl + Alt + NumpadDel (Both NumLock states) Invoke the task manager. More commonly known as the AltTab dialog. Your selected folder will be opened in a new window.Īnother method is to press and hold the Ctrl key, then double-click your target folder to open it in a new window. Enter clicks, AppsKey or Shift + F10 right-clicks. Right-click its icon and select the 'Delete Folder' option. ![]() You can find it on the sidebar and under Inbox (or any other folder). (J) Not selected Downloads not selected documents shell folder view items view listbox. Firstly, launch Outlook on your system and simply navigate to the folder you wish to delete. Use your cursor to select the desired folder, then press the Ctrl + Enter (or Ctrl + N) keyboard shortcut. Press the File Explorer keystroke CTRL+SHIFT+N to create a new folder. Method 3: Temporarily Open a Folder in New Window via Keyboard Shortcut It will temporarily open your folder in a new window. Just right-click your desired folder in File Explorer, and then choose “ Open in new window” from the pop-up context menu. Method 2: Temporarily Open a Folder in New Window via Context Menu Activate the LMDExpandedHotkeys.esp file in either your mod manager of choice or the games launcher, then start the game. This folder is under your Steam installation like this: SteamsteamappscommonFallout new vegasData Make sure New Vegas Script Extender (NVSE) is installed. Click OK.įrom now on, Windows will always open each folders in a new window by default. Extract the archive to your Fallout New VegasData folder. In the General tab, select “ Open each folder in its own window“. I also think it would make more sense for this feature to be part of Templater, rather than hotkeys for templates, but that might just be me. ![]() I am not sure why, but I cant get recursive defaults to work consistently with hotkeys for templates. Press the Windows key + R keyboard combination to invoke the Run command box, type control.exe folders and hit Enter to open Folder Options. This is how we decided to do it in the Hotkeys for Templates plugin, see Vinzent03/obsidian-hotkeys-for-templates7. Select Auto Action in the Setting Area pull-down. This will start the Create Shortcut wizard. Can I create an auto action Open Shortcut Setting from the CLIP STUDIO PAINT menu. Method 1: Always Open Folders in New Window To create a new shortcut on the desktop, right click on an empty area of the desktop and select New, Shortcut. This is a Windows shortcut and works in most programs it will also bring up the Shutdown window, which is handy in Windows 8. If you prefer opening folders in a new window, here are 3 fast methods available on Windows 11. Ctrl+4, 5, 7, and 8 ( 9 if you use BCM) cover the rest of the navigation pane modules. Is there a keyboard shortcut to open folders up in a new window? When you double-click a folder in File Explorer, the default option is to open each folder in the same Window. ![]() ![]() In the True Lawful ending of Catherine Classic, Vincent and Katherine end up getting married at the Stray Sheep bar. Toby is much younger than the other three, and has his heart set on the redhead waitress at their favorite bar, Erica, who went to school with Jonny, Orlando, and Toby.Įrica is a trans woman. Orlando is a cynical player who went through a messy divorce and thinks marriage is bad. Jonny is a cynical man who had a crush on Katherine in school but now feels he’s uninterested in relationships. None are especially given much development, but it’s worth noting their character archetypes. Joining Vincent on his journey are his (dirtbag) friends Jonny, Orlando, and Toby. Vincent, afraid of commitment, ends up falling into a tryst with a blonde girl named…Catherine. Katherine, you see, is ready to tie the knot but wants Vincent to propose. In Catherine, you assume the role of protagonist Vincent Brooks, a software engineer who has been dating his longtime girlfriend Katherine for many years. Persona 5 inserts a pair of unnamed effeminate male NPCs to chase and harass one of the male party members in the hopes that the audience will laugh.Ĭatherine Classic features another clear look at how the writers and project leaders view trans people. I could write 4,000 words just on the portrayal of Kanji as definitely not a gay character who is portrayed with incredibly dated queer male stereotypes, while party members get grossed out and mock him about it for the duration of the game. In Persona 4, despite the localization team at Atlus USA’s best efforts, there are many frustrating struggles with the sexuality of party member Kanji Tatsumi, as well as the gender identity of detective Naoto Shirogane. Persona 3 includes a random throwaway (yet unskippable) interaction with a trans woman who is portrayed as a predator to the unwitting and ‘victimized’ male protagonists. Games directed by and produced by Hashino-san, the new studio lead of Atlus’ Studio Zero, have had many problems with LGBTQIA+ representation. ![]() It is free of cost and is the Martian equivalent of the Trail. ![]() Having a high amount of Life Support means that the player will receive a discount while producing goods on the Outpost.Īll buildings and structures in the Mars Outpost are connected via the Carved Road. Life Support buildings provide the player with Life Support, the Space equivalent of Happiness. The production also requires Mars Ore, which may be obtained from the Continent Map, via negotiating/fighting Provinces. Goods Buildings of Mars require goods deposits which are found as rewards of Provinces on the Continent Map. Aside from that, they also provide Colonists, which is the Space equivalent of Population. They are required for advancing in the Continent Map. Residential Buildings on the Outpost produce Credits, a kind of Space Colony currency. Production Buildings New Horizons Centerīuildings on Mars Outpost Residential Buildings Requirements Requirements for Researchīuildings on Earth Residential Buildings Adaptive Home It is needed to produce Mars goods and for research. Different exploration sites may be explored at the same time.Įxploration sites are the only renewable source of Mars Ore in this age. A new exploration to the same exploration site may be started immediately afterwards again. After the exploration time is over, an encounter has to be solved by negotiating or fighting to obtain Mars Ore from the exploration site. Starting an Exploration costs some Credits. Several of the provinces of the map of Space Age Mars contain exploration sites.Īfter a province with an exploration site is owned by a player, an exploration may be started to that site. ![]() Game Hack Features Baseball Superstars® 2013 MOD Developed by Com2uS Holdings Corporation. * Additional charges may apply when attempting to obtain certain items.įree download Baseball Superstars® 2013 for Android APK & Iphone IOS IPA. – CONTACTS: For logging into Com2uS Holdings – STORAGE: For saving game data to external storage etc. When using the app, we may ask for permission to provide the following services. If you delete the game without backing up the data, the data will be initialized and the existing data will not be restored. If you change Mobile phone information, etc., existing data will not be able to be linked.Ģ. In the improved My Hitter & My Pitcher mode, perfect your skills as you play with your own super players !Ĭhallenge players to your friends and others to improve your stats and win big!ĭive into casual baseball as you meet new characters, woo the ladies, and enter the Hall of Fame Creation!ġ. Touch My Hitter & My Intuitive Pitcher Mode Play baseball endlessly with crisp and vivid HD graphics!Ĭomplete quests and daily quests to get high scores! Join millions of fans around the world in this epic baseball RPG experience! Grow from rookie to superstar by tackling new missions and building relationships with your fans and cohorts! With the new and improved My Pitcher and My Hitter modes, you’ll experience the best of both worlds as you train, challenge and fight for the top spot. With improved batting and throwing motions, players can experience a smart, intuitive baseball experience like never before. This is the best mobile baseball game in high definition. The long-awaited Baseball Superstars series is back and better than ever! The Ultimate Smart Baseball Experience is Back Download Baseball Superstars® 2013 Mod 1.2.7 for android apk & iphone ios 4.1 |
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